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Embarking on the journey to parenthood is a cherished aspiration for many couples across India. However, the stigma associated with infertility can lead to profound psychological and emotional distress, affecting not just the individuals directly involved but their entire families.

Thanks to groundbreaking scientific advancements in human reproduction, countless individuals now can realize their dreams of starting a family. Despite this, there is still a significant barrier: the accessibility of such treatments, particularly in rural areas, leaves many without the chance to receive help from these revolutionary therapies.

The Challenge of Infertility in India

India faces a critical challenge with infertility affecting approximately 10-15% of married couples. This translates to around 27.5 million couples each year who may seek treatment for infertility.

Factors contributing to this include delayed marriages, increased use of contraceptives, the rising number of career-oriented women, and lifestyle changes such as higher consumption of tobacco and alcohol. Conditions like polycystic ovarian syndrome (PCOS), obesity, and sexually transmitted infections are more prevalent among younger women, further complicating fertility issues.

Facing the Reality: Infertility Treatment Outcomes in India

Regarding the success rates of infertility treatments, there are notable differences between Indian and Caucasian populations, with Indian women experiencing lower implantation rates, clinical pregnancy rates, and live birth rates. Such disparities underscore the urgent need for enhanced fertility care and access to advanced reproductive technologies in India.

Navigating Infertility Treatment in India

It is well known that Indian ethnicity brings along with it a poorer ovarian reserve as compared to Caucasian women, leading to poorer outcomes of infertility treatment.

Several theories exist about the possible cause for subfertility in the Indian population compared to Caucasians seen in these studies. One common theory is a higher incidence of PCOS in Indian women. Several studies recognize a higher incidence of PCOS in Indian women compared to other ethnicities. PCOS is a complex, multifaceted metabolic disorder associated with insulin resistance, hyperandrogenism, and ovulation dysfunction leading to subfertility. Women of Indian ethnicity seem to be more sensitive to the metabolic effects of this disorder.

Some research suggests that a high incidence of genital tuberculosis (TB) in the Indian population may explain subfertility in that population. And in a study of 300 women in Bombay, they were evaluated for tubal factor as a cause of infertility.

39% of Indian women were found to have genital TB diagnosed from laparoscopic specimens.

The following chart compares Caucasian vs Indian success rates:

Variable Caucasian Indian
Implantation Rate 39% 28%
Positive HCG* 61% 53%
Clinical Pregnancy* 52% 36%
SABˆ 22% 31%
Live Birth Rate* 41% 24%
Multiple Pregnancy* 12% 9%

*Per embryo transfer.

ˆper clinical pregnancy.

As a result of these medical issues, many females in India have little choice but to resort to the use of IVF, and if that is not successful, to use Egg Donors to create embryos and surrogate mothers, as needed, to carry a baby for them.

Egg donation is now permitted in India for surrogacy as per the new India Supreme Court Ruling dated February 21st, 2024. But keep in mind that the egg donors are part of the Indian female population.

With 39% of Indian women having genital Tuberculosis, along with the other issues listed above, the chance of a live birth is likely to be only 24%, as shown in the above chart, versus 41% in Caucasian women.

Keep in mind that one reason for the much higher success rate in the USA, close to 70% for egg donors, is the FDA required testing of egg donors including genetic testing, prior to donation.

Q: Why does the FDA in USA require testing of egg donors? What are the tests?

The FDA (U.S. Food and Drug Administration) requires testing of egg donors to ensure the safety of the egg donation process and to protect the health of the recipient and the resulting child. These regulations are part of the broader effort to ensure the safety of human cells, tissues, and cellular and tissue-based products (HCT/Ps) by reducing the risk of transmission of infectious diseases.

Tests Required for Egg Donors

The FDA mandates a series of tests for egg donors, including but not limited to:

  • Infectious Disease Testing: To screen for HIV, hepatitis B and C, syphilis, and other infectious diseases that could be transmitted to the recipient or the child.
  • Genetic Testing: To identify potential genetic disorders or abnormalities that could be passed on to the child.
  • Drug and Nicotine Testing: To ensure the donor does not use substances that could harm the egg's quality or affect the health of the baby.
  • General Health Screening: To assess the overall health and suitability of the donor, including her ability to safely undergo the egg retrieval process.

Pros of Testing Egg Donors

  • Increased Safety: Testing significantly reduces the risk of transmitting infectious diseases to the recipient and the child.
  • Informed Decisions: Genetic testing allows for informed decisions by prospective parents regarding potential genetic risks.
  • Quality Assurance: Ensures the high quality and viability of donated eggs, increasing the chances of a successful pregnancy.
  • Regulatory Compliance: Helps fertility clinics and agencies remain compliant with FDA regulations, ensuring a standardized level of care and safety.

Cons of Testing Egg Donors

  • Cost: The extensive testing required can significantly increase the overall cost of the egg donation process, making it less accessible for some individuals or couples.
  • Privacy Concerns: The need for detailed personal and health information may raise privacy concerns for some donors.
  • Potential Discrimination: Genetic testing can lead to ethical and moral dilemmas, including the potential for discrimination based on genetic traits.
  • Emotional Stress: The testing process can be emotionally stressful for donors, who may worry about the results of their tests and the impact on their eligibility to donate.

In summary, the FDA's requirement for testing egg donors is a critical component of ensuring the safety and success of the egg donation process. While there are significant benefits to these regulations, including reduced risk of disease transmission and increased chances of a healthy pregnancy, there are also drawbacks, such as increased costs and potential emotional stress for donors. These factors all play a crucial role in the ethical, legal, and medical considerations surrounding egg donation.

Q: If I am going to India for egg donation and IVF, should I insist on using a clinic that does FDA level testing?

Without question! Opting for an egg donation and IVF clinic in India that adheres to FDA-level testing standards can be a prudent choice, especially if you prioritize safety, quality, and the reduction of risks associated with genetic testing, egg donation and IVF procedures. Here are several reasons why insisting on such a clinic might be beneficial for you:

Advantages of Choosing a Clinic with FDA-level Testing

  • Enhanced Safety: Clinics that follow FDA-level testing protocols likely have higher standards for screening egg donors for infectious diseases, genetic conditions, and overall health. This reduces the risk of disease transmission to you and your future child.
  • Quality Assurance: These clinics are more likely to ensure that the eggs used are of the highest quality, potentially increasing the chances of a successful pregnancy and healthy baby.
  • Informed Decision Making: Having detailed information about the donor's health and genetic background can help you make informed decisions throughout the IVF process.
  • International Standards: Clinics that adhere to international standards may offer a higher level of care and use advanced technologies and practices, enhancing the overall success rate of the procedures.
  • Ethical Practices: FDA-level standards include ethical considerations in donor recruitment, compensation, and consent processes, ensuring that donors are treated fairly and ethically.

Considerations and Potential Limitations

  • Cost: Be prepared that clinics with higher standards for testing and quality may charge more for their services. This could significantly increase the overall cost of the egg donation and IVF process.
  • Accessibility: Not all clinics may offer FDA-level testing, especially in regions with less stringent regulations. You may need to do thorough research or seek recommendations to find a suitable clinic.
  • Regulatory Differences: While some clinics may strive to meet international standards, it's important to recognize that regulatory environments differ. Clinics in India operate under Indian regulations, which may not align perfectly with FDA requirements.

Recommendations

  • Research and Verification: Conduct thorough research on clinics, focusing on their testing protocols, success rates, and reviews from previous clients. Verify their claims regarding adherence to FDA-level standards or any international benchmarks.
  • Consultation: Before making a decision, consult with the clinics directly. Ask specific questions about their testing protocols, donor screening processes, and how they manage risks associated with egg donation and IVF.
  • Legal and Ethical Considerations: Ensure the clinic follows ethical guidelines for egg donation and IVF, respecting both donors' and recipients' rights and well-being.
 

There are only two clinics in India that do FDA level testing. The samples from the egg donor are physically sent to a CLEA Certified Lab in the USA by FedEx prior to the frozen eggs being used to create embryos. Kindly contact us for referrals at info@indianeggdonors.com

FAQ's

FAQs about IVF, Surrogacy, and Egg Donation in India

It's essential to select an IVF center wisely in India. Many centers lack certification, have outdated equipment, do not do FDA testing, do not do genetic testing of donors, and as a result, have low success rates. Having an unsuccessful IVF journey can be emotionally and financially draining, making it crucial to choose a center with a proven track record of success.

Indian laws regarding surrogacy and egg donation have undergone significant changes since 2015, with updates continuing through February 2024. These laws impact who can access assisted reproduction based on factors like age and marital status. Here's a summary:

  • Commercial surrogacy is prohibited, limiting surrogacy to altruistic arrangements.
  • Surrogacy is only available to heterosexually married Indian couples and single women, with proven infertility.
  • Surrogacy is not permitted for single male individuals, live-in couples, or same-sex couples. They have to seek surrogacy outside India.
  • Sex selection is strictly prohibited.
  • Intended couples must meet specific age and marital requirements.
  • Surrogacy is legal in India for NRI's with Indian passports, and Indians with American, British, and other passport holders who have OCI Cards
  • IVF is legal for all nationalities that meet the above restrictions.

This can vary from a low of $8,000 for just an IVF cycle, $16,000 for an IVF Cycle with an egg donor, to $61,000 for a complete IVF and surrogacy Cycle, using an egg donor, surrogate mother, and extensive medical and genetic testing to ensure a healthy baby. The same protocol in the USA would cost around $160,000. So by using an FDA-certified lab in India, you are getting American standard IVF, at one-third of the USA price. Add about $2,000 for Genetic and FDA testing for samples shipped to the USA for FDA testing

Yes, no restrictions based on nationality. However other restrictions apply based on marital status and age.

For individuals who do not qualify for reproductive treatment in India or prefer alternatives, reputable agencies like ours offer programs in countries like the USA and Canada. These programs provide legal surrogacy services, sex selection, and may be suitable for those seeking different eligibility criteria or preferences.

IVF success rates in India vary between clinics. It's crucial to choose a clinic with a proven track record of success, as some centers may have lower success rates due to outdated equipment or substandard practices.

The IVF treatment process in India typically involves initial consultations, ovarian stimulation, egg retrieval, fertilization in the laboratory, embryo transfer, and monitoring. Each step is carefully managed by experienced medical professionals.

When selecting an IVF clinic, consider factors such as accreditation, success rates, patient reviews, and the expertise of the medical team. It's essential to choose a clinic that prioritizes patient care and safety.

Indian laws regarding IVF treatment, including surrogacy, egg donation, and embryo storage, have undergone recent changes. These laws impact who can access assisted reproduction based on factors like age, marital status, and eligibility criteria.

Certain medical conditions or age limits may affect eligibility for IVF treatment in India. It's important to consult with a healthcare provider to determine if IVF is a suitable option based on individual circumstances.

In addition to IVF, alternative assisted reproductive options in India may include adoption or exploring options outside of India, such as legal surrogacy services in countries like the USA and Canada.

Potential risks of IVF treatment include ovarian hyperstimulation syndrome, multiple pregnancies, and emotional stress. These risks should be discussed with a healthcare provider before starting treatment.

Many IVF clinics in India provide emotional support and counseling services to help patients cope with the stress and emotional challenges associated with infertility and assisted reproduction.

After completing an IVF cycle, patients can expect follow-up care and monitoring to assess the outcome of treatment and provide any necessary support or adjustments to future treatment plans.

 

Call us at 1-212-661-7177 or send us an email to info@indianeggdonors.com to receive the Forms and paperwork to start IVF in India.

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